Understanding a rare hematological malignancy like Plasma Cell Leukemia from simple complete blood count (CBC) analysis by utilizing hematology analyzer cell data, scatter plot, and flagging system. HORIBA Medical's Yumizen Hematology systems are capable and equipped to perform sub-lineage white blood cells differentials like immature lymphocytes (IML), immature monocytes (IMM) and immature granulocytes (IMG) which can help in subclassification of hematology malignancy at preliminary stage, to further decide for specific confirmatory test for final diagnosis and accurate clinical management.